Doç. Dr. Erdem Coşkun

Gazi Üniversitesi Eczacılık Fakültesi’nden 2002 yılında mezun olmasının ardından, aynı fakültenin Toksikoloji Anabilim Dalı’nda bilimsel kariyerine başladı. Yüksek lisansın ardından aynı bülümde başladığı doktorasının bir kısmını İtalya/Roma’da bulunan IRCCR San Raffaele Enstitüsünde (günümüzdeki adıyla San Raffaele Üniversitesi) tamamladı. Doktorasının ardından, 2014 yılında, Amerika Birleşik Devletleri’nde bulunan National Institute of Standards and Technology kurumuna DNA hasarı ve onarımı üzerine araştırmalar yapmak üzere davet edildi. 2019 yılında, NIST ve University of Maryland’in ortak ...

Makaleler

Chapter Twelve Production Purification and Characterization of 15N Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements , 2016
Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics , 2017
Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways , 2017
Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1 , 2020
Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1 , 2020
Measurement of Oxidatively Induced DNA Damage in iCaenorhabditis elegans/i with High-Salt DNA Extraction and Isotope-Dilution Mass Spectrometry/title , 2019
Identification and quantification of DNA repair protein poly(ADP ribose) polymerase 1 (PARP1) in human tissues and cultured cells by liquid chromatography/isotope-dilution tandem mass spectrometry , 2019
Characterization of rare NEIL1 variants found in East Asian populations , 2019
Excision release of 5?hydroxycytosine oxidatively induced scpDNA/scp base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation/title , 2018
Biomarkers of oxidatively induced DNA damage in dreissenid mussels: A genotoxicity assessment tool for the Laurentian Great Lakes , 2017
Aflatoxin-Guanine DNA Adducts and Oxidatively Induced DNA Damage in Aflatoxin-Treated Mice iin Vivo/i as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope Dilution/title , 2018
Can sevoflurane induce micronuclei formation in nasal epithelial cells of adult patients? , 2017
Combined Effects of High Dose Bisphenol A and Oxidizing Agent KBrO3 on Cellular Microenvironment Gene Expression and Chromatin Structure of Ku70 deficient Mouse Embryonic Fibroblasts , 2016
Comparisons of the effects of the sevoflurane and propofol on acute ischemia reperfusion and DNA damages in rabbits , 2017
Production Purification and Characterization of 15N Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements , 2015
Bisphenol A Promotes Cell Survival Following Oxidative DNA Damage in Mouse Fibroblasts , 2015
Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography isotope dilution tandem mass spectrometry , 2015
Extreme Expression of DNA Repair Protein Apurinic Apyrimidinic Endonuclease 1 APE1 in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry , 2015
Measurement of oxidatively induced DNA damage and its repair by mass spectrometric techniques , 2015
Launch of the ComNet comet network project on the comet assay in human population studies during the International Comet Assay Workshop meeting in Kusadasi Turkey September 13 16 2011 , 2012
Small Molecule Inhibitors of 8 Oxoguanine DNA Glycosylase 1 OGG1 , 2015
Increased micronucleus frequencies in surrogate and target cells from workers exposed to crystalline silica containing dust , 2010
Genomic instability in quartz dust exposed rat lungs Is inflammation responsible , 2009
ADRA2A polymorphism and smoking in a Turkish population , 2008
NanoLINEN Nanotoxicology Link Between India and European Nations , 2011
Micronucleus frequencies in lymphocytes and buccal epithelial cells from patients having head and neck cancer and their first degree relatives , 2011
The HUman MicroNucleus project on eXfoLiated buccal cells HUMNXL The role of life style host factors occupational exposures health status and assay protocol , 2011
Determination of DNA damage after exposure to inhalation anesthetics in human peripheral lymphocytes and sperm cells in vitro by comet assay , 2012
Assessment of Individual Susceptibility to Baseline DNA and Cytogenetic Damage in a Healthy Turkish Population Evaluation with Lifestyle Factors , 2012
Effects of different doses of trehalose supplementation in egg yolk extender in frozen thawed Angora buck semen , 2013
Effects of various cryoprotectants on bull sperm quality DNA integrity and oxidative stress parameters , 2013
The comet assay as a tool for human biomonitoring studies The ComNet Project , 2014
Comparison of Cryoprotective Effects of Lycopene and Cysteamine in Different Cryoprotectants on Bull Semen and Fertility Results , 2014
Can linoleic acid improve the quality of frozen thawed bull sperm , 2014
Could 8 oxoguanine DNA glycosylase 1 Ser326Cys polymorphism be a biomarker of susceptibility in cancer , 2014
OGG1 genetic polymorphism in workers exposed to crystalline silica containing dust is not associated with silicosis in exposed workers , 2008
Alpha 2A adrenergic receptor gene ADRA2A polymorphism in a Turkish population , 2008
Baseline cytogenetic profiles of a healthy Turkish population by three test systems Comparison between assays , 2008
Investigation of oxidative DNA damage in crystalline silica containing dust exposed workers , 2007
Micronucleus frequencies in exfoliated buccal cells of head and neck cancer patients and their first degree relatives , 2007
Influence of XRCC1 Arg399Gln polymorphism on basal and radiation induced micronucleus frequencies in head and neck cancer patients and their first degree relatives , 2006
In vivo lung genotoxicity of quartz using the micronucleus assay , 2005
The radiation induced chromosome damage in head and neck cancer patients and healthy subjects , 2005

Bildiriler

Measurement of DNA Repair Proteins in Relation to Disease Biomarkers and Drug Development - COŞKUN ERDEM
Identification and quantification of MTH1 in human tissues as a cancer biomarker - COŞKUN ERDEM,Ann Sofie Jemth,Loseva Olga,Jaruga Pawel,Scanlan Leaona,Halleday Thomas,Dizdaroglu Miral
In vivo genotoxicity of Quartz in rats and crystalline silica containing dust in workers - ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,Albrecht C,Knaapen AM,Becker A,NURI VIDINLI,ERBAS Y,Yilmaz M,PJA Borm,RPF Schinz,BURGAZ SEMA
Identification and quantification of MTH1 in human tissues as a cancer biomarker - COŞKUN ERDEM,Ann Sofie Jemth,Loseva Olga,Jaruga Pawel,Scanlan Leaona,Halleday Thomas,Dizdaroglu Miral
Influence of XRCC1 Arg399Gln Polymorphism on Basal and Radiation Induced Micronucleus Frequencies in Head and Neck Cancer Patients and Their First Degree Relatives - COŞKUN ERDEM,BURGAZ SEMA,Kocabas Neslihan,ÇAKMAK DEMİRCİGİL GONCA,Cetindag Faik,Osman Sunter,Edinsel Hayriye
Basal and Radiation Induced Chromosomal Damage in First Degree Relatives of Head and Neck Cancer Patients - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan Kocabas,BURGAZ SEMA
Micronucleus frequencies in surrogate and target tissues of workers exposed to crystalline silica containing dust - ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,Nuri Vidinli,Erbas Y,RPF Schinz,PJA Borm,BURGAZ SEMA
Assessment of the optimum dose for chromosomal radiosensitivity assay and induced micronucleus frequencies in head and neck cancer patients - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan Kocabas,BURGAZ SEMA
Extreme Expressions of DNA Repair Proteins APE1 and MTH1 in Human Breast Cancer as Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry - COŞKUN ERDEM,Ann Sofie Jemth,Loseva Olga,Jaruga Pawel,Scanlan Leaona,Halleday Thomas,Dizdaroglu Miral
Identification and quantification of MTH1 in human tissues by LC MS MS with isotope dilution - COŞKUN ERDEM,Ann Sofie Jemth,Loseva Olga,Jaruga Pawel,Scanlan Leaona,Halleday Thomas,Dizdaroglu Miral
Measurement of human MTH1 protein by LC MS MS with isotope dilution - COŞKUN ERDEM,Ann Sofie Jemth,Jaruga Pawel,Scanlan Leaona,Halleday Thomas,Dizdaroglu Miral
Effects of Various Cryoprotectants on Bull Sperm Quality DNA Integrity and Oxidative Stress Parameters - COŞKUN ERDEM,al et
Effect of Nanoparticle Size on the Cytotoxicity of Titanium Dioxide on Neuronal Cells in Cell Culture - ENGİN AYŞE BAŞAK,COŞKUN ERDEM,KARAHALİL BENSU,Karakaya Ali Esat
Evaluation of Genotoxicity in Infertile Male - COŞKUN ERDEM,Bonassi Stefano,Dall Armi Valentina,KARAHALİL BENSU,Cihan Kabukcu,Karakaya Ali Esat
Assessment of Titanium Dioxide Cytotoxicity on Neuronal Cells in Cell Culture - ENGİN AYŞE BAŞAK,COŞKUN ERDEM,Karakaya Ali Esat,KARAHALİL BENSU
NanoLINEN NANOTOXICOLOGY LINK BETWEEN INDIA AND EUROPEAN NATIONS An International Collaborative Project funded by EC FP7 - COŞKUN ERDEM,et al
Effects of sevoflurane and propofol on acute ischemia reperfusion and DNA damage in rabbits 4AP2 2 - Oncul S,Lale Karabiyik,COŞKUN ERDEM,KADIOĞLU ELA,Gulbahar O
Genetic instability in the peripheral lymphocytes and buccal cells of head and neck cancer patients and their first degree relatives influence of XRCC1 Arg399Gln polymorphism - BURGAZ SEMA,AN KOcabas,COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel
Genetic instability in the peripheral lymphocytes and buccal cells of head and neck cancer patients and their first degree relatives influence of XRCC1 Arg399Gln polymorphism - BURGAZ SEMA,AN KOcabas,COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel
Baseline cytogenetic profiles of healthy Turkish population by three test systems comparison between assays - COŞKUN ERDEM,KADIOĞLU ELA,ÇAKMAK DEMİRCİGİL GONCA,ÖZÇAĞLI EREN,DURMAZ EMRE,KARAHALİL BENSU,BURGAZ SEMA,ŞARDAŞ SEMRA,Neslihan Aygun-Kocabas
Alpha 2A adrenergic receptor gene ADRA2A polymorphism in a Turkish population - EMERCE GÜRSEL ESRA,KARAHALİL BENSU,COŞKUN ERDEM
OGG1 genetic polymorphism in workers exposed to crystalline silica containing dust is not associated with silicosis in exposed workers - ÇAKMAK DEMİRCİGİL GONCA,KADIOĞLU ELA,COŞKUN ERDEM,Nuri Vidinli,Yildiray Erbas,Arif Cimrin,Roel PF Schins,Paul JA Borm,BURGAZ SEMA
Deciduous teeth lead levels in children as a biomarker of environmental lead pollution - COŞKUN ERDEM,Banu Aykanat,ERTAŞ NUSRET,KARAHALİL BENSU
Investigation of oxidative DNA damage in crystalline silica containing dust exposed workers - ÇAKMAK DEMİRCİGİL GONCA,KADIOĞLU ELA,COŞKUN ERDEM,Nuri Vidinli,Erbas Yildiray,Schins Roel PF,Borm Paul JA,BURGAZ SEMA
Micronucleus frequencies in exfoliated buccal cells of head and neck cancer patients and their first degree relatives - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan A Kocabas,BURGAZ SEMA
Micronucleus frequencies in exfoliated buccal cells of head and neck cancer patients and their first degree relatives - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan Kocabas,BURGAZ SEMA
Bleomycin induced chromosomal aberrations frequencies in a Turkish population - DURMAZ EMRE,KARAHALİL BENSU,ÖZÇAĞLI EREN,ÇAKMAK DEMİRCİGİL GONCA,KADIOĞLU ELA,COŞKUN ERDEM,ŞARDAŞ SEMRA,BURGAZ SEMA,AN Kocabas
DNA effect biomarkers for crystalline silica containing dust exposed workers in Turkey - ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,Nuri Vidinli,Erbas Y,RPF Schinz,PJA Borm,BURGAZ SEMA
Assessment of the optimum dose for chromosomal radiosensitivity assay and induced micronucleus frequencies in head and neck cancer patients - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan Kocabas,BURGAZ SEMA
Influence of XRCC1 Arg399Gln Polymorphism on Basal and Radiation Induced Micronucleus Frequencies in Head and Neck Cancer Patients and Their First Degree Relatives - BURGAZ SEMA,Kocabas Neslihan,COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Cetindag Faik,Osman Sunter,Edinsel Hayriye
Influence of XRCC1 Arg399Gln Polymorphism on Basal and Radiation Induced Micronucleus Frequencies in Head and Neck Cancer Patients and Their First Degree Relatives - ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,Knaapen AM,Becker A,BURGAZ SEMA,NURI VIDINLI,ERBAS Y,Yilmaz M,PJA Borm,RPF Schinz
In vivo lung genotoxicity of Quartz using the micronucleus assay - ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,Albrecht C,Knaapen AM,Becker A,BURGAZ SEMA,PJA Borm,RPF Schinz
Does occupational exposure to crystalline silica containing dust induce cytokinesis blocked micronucleus frequency - ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,Nuri Vidinli,Erbas Y,RPF Schinz,PJA Borm,BURGAZ SEMA
The radiation induced frequencies of micronuclei and nucleoplasmic bridges in head and neck cancer patients and healthy subjects - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan Kocabas,BURGAZ SEMA
The radiation induced frequencies of micronuclei in head and neck cancer patients and healthy subjects - COŞKUN ERDEM,ÇAKMAK DEMİRCİGİL GONCA,Faik Cetindag,Osman Sunter,Hayriye Edinsel,Neslihan Kocabas,BURGAZ SEMA
Effect of glutathione S transferase GST polymorphisms on choromosomal aberrations and micronucleus frequencies in a Turkish population - Kocabas AN,ÖZÇAĞLI EREN,ÇAKMAK DEMİRCİGİL GONCA,COŞKUN ERDEM,KADIOĞLU ELA,DURMAZ EMRE,KARAHALİL BENSU,BURGAZ SEMA,ŞARDAŞ SEMRA
Relationship between Male Reproductive System and Nanomaterials - COŞKUN ERDEM
Male Infertility and Genetic Factors - COŞKUN ERDEM
Androgen Receptor CAG n Repeat Lengths and Sperm Chromatin Integrity Possible Risk Factors For Male Infertility - COŞKUN ERDEM
Most Popular Cytogenetic Biomarkers - COŞKUN ERDEM

Kitaplar

Toksikolojinin Temelleri – Ankara Nobel Tıp Kitapevleri
casarett and doull s essentials of toxicology – Ankara Nobel Tıp Kitabevleri
Methods in Enzymology Isotope Labeling of Biomolecules Applications – Elsevier

Ödüller

Butunlestirilmis Doktora Burs Programi – 2005
2219-Yurt Dışı Doktora Sonrası Araştırma Burs Programı – 2014
International Scholarship Program – 2010
Dr. Nejat Yazıcıoğlu İşçi SağlığıAraştırma Ödülü – 2010
Best Collaborative Study Award – 2005
Travel Award – 2015
MML Postdoctoral Fellow Accolade – 2018

Doç. Dr. Erdem Coşkun - İstinye Üniversitesi

erdem.coskun@istinye.edu.tr

Çalışma Alanları

Sağlık Bilimleri Temel Alanı / Farmasotik Toksikoloji

Akademik Personel

Eczacılık Meslek Bilimleri

Makaleler

Bildiriler

Kitaplar

Ödüller

Çalışma Alanları