Prof. Dr. Engin Ulukaya, 1987 yılında mezun olduğu İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesini takiben Uludağ Üniversitesinde Tıbbi Biyokimya uzmanlığını bitirmiştir. University of Leeds (UK), School of Biochemistry and Molecular Biology’de doktora (PhD) eğitimini tamamlamıştır. Temel kanser araştırmaları, hücre ölümü, kanser ilaç geliştirme, ve kişiye yönelik onkoloji alanlarında çalışmalar yapmaktadır. Moleküler kanser araştırma derneği (MOKAD) başkanlığının yanısıra, EACR (European Association for Cancer Research)’de Konsey Üyesi ve EORTC PathoBiology alt grubu asil üyesidir. Uluslarar...
Prof. Dr. Engin Ulukaya, 1987 yılında mezun olduğu İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesini takiben Uludağ Üniversitesinde Tıbbi Biyokimya uzmanlığını bitirmiştir. University of Leeds (UK), School of Biochemistry and Molecular Biology’de doktora (PhD) eğitimini tamamlamıştır. Temel kanser araştırmaları, hücre ölümü, kanser ilaç geliştirme, ve kişiye yönelik onkoloji alanlarında çalışmalar yapmaktadır. Moleküler kanser araştırma derneği (MOKAD) başkanlığının yanısıra, EACR (European Association for Cancer Research)’de Konsey Üyesi ve EORTC PathoBiology alt grubu asil üyesidir. Uluslararası saygın hakemli dergilerde yaklaşık 200 makale yayınlamıştır (Google Scholar H indeks:48, alınan atıf sayısı:7020, Nisan 2025). 2003 yılında Güney Kore’de düzenlenen dünya patoloji ve laboratuvar tıbbı derneği (WASPALM) kongresinde “gelecek vaat eden laboratuvar hekimi” ödülünü almış ve WASPALM madalyasına hak kazanmıştır. Ayrıca 3’ü yurt dışı, 32 adet çeşitli kategorilerde ödülü bulunmaktadır. İstinye Üniversitesi Sağlık Bilimleri Dekanlığı görevini yürütmektedir. Ayrıca aynı üniversitenin Moleküler Kanser Uygulama ve Araştırma Merkezi (İSÜMKAM) Direktörüdür.
Makaleler
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
, 2017
Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
, 2017
Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium Quercetorum Agnew in Human Breast Cancer Cells
, 2017
A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
, 2017
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
, 2018
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
, 2018
Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
, 2017
A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
, 2017
Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line
, 2017
Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents
, 2017
The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine
, 2017
Synthesis, structures, DNA/protein binding, molecular docking, anticancer activity and ROS generation of Ni(II), Cu(II) and Zn(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl) amine and terpyridine
, 2017
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
, 2017
A palladium(II)–saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model
, 2017
Usnea filipendula Induces Apoptosis in Human Colon Cancer Cell Lines.
, 2018
Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis
, 2021
Folic acid-conjugated Cationic Ag2S Quantum Dots for Optical Imaging and Selective Doxorubicin Delivery to HeLa Cells
, 2017
Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage
, 2018
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells.
, 2018
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
, 2017
Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line.
, 2017
Combination of esomeprazole with chemotherapeutics results in more pronounced cytotoxic effect via apoptosis on A549 nonsmall-cell lung cancer cell line
, 2017
Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)-2,2\u2032:6\u2032,2\u2033-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker
, 2018
The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation
, 2022
Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans
, 2022
Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis
, 2022
Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
, 2022
DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives
, 2022
Synthesis, DNA Binding and Cytotoxic Activity of Newcopper(II) Complexes of Trisubstituted Imidazoles
, 2022
Novel 5-fluorouracil complexes of Zn(II) with pyridine-based ligands as potential anticancer agents
, 2022
Pyruvate Dehydrogenase Contributes to Drug Resistance of Lung Cancer Cells Through Epithelial Mesenchymal Transition
, 2022
Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells
, 2022
Effects of Exosomes on Major Pathways Promote Tumor Formation and Progression
, 2022
Preparation and Characterization of Palladium Derivate-Loaded Micelle Formulation in Vitro as an Innovative Therapy Option against Non-Small Cell Lung Cancer Cells
, 2021
Palladium (II) complex and thalidomide intercept angiogenic signaling via targeting FAK/Src and Erk/Akt/PLC gamma dependent autophagy pathways in human umbilical vein endothelial cells
, 2021
Anticancer Potential of Albumin Bound Wnt/beta-Catenin Pathway Inhibitor Niclosamide in Breast Cancer Cells
, 2021
Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies
, 2021
Tumor Chemosensitivity Assays Are Helpful for Personalized Cytotoxic Treatments in Cancer Patients
, 2021
Epigenetic modulators combination with chemotherapy in breast cancer cells
, 2021
Soloxolone methyl, as a 18 beta H-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells
, 2021
Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis
, 2021
Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects via Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells
, 2021
Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5-diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach
, 2021
Investigation of the efficacy of paclitaxel on some miRNAs profiles in breast cancer stem cells
, 2021
Etoposide Loaded SPION-PNIPAM Nanoparticles Improve thein vitroTherapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis
, 2020
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex
, 2020
Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling
, 2020
Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship
, 2020
Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines
, 2020
Cytotoxic platinum(II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosis
, 2020
Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand
, 2020
Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis
, 2021
Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity
, 2020
An Investigation of Anticancer Effects of Doxorubicin and Calcitriol Combination on MCF-7 Cells
, 2018
Lichens exerts on anti - proliferative effect on human breast and lung cancer cells through induction of apoptosis
, 2019
Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity
, 2020
Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines
, 2019
Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes
, 2019
Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines
, 2019
Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines
, 2019
Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
, 2019
Synthesis and investigation of cytotoxicity of New N- and S,S-substituted-1,4-Naphthoquinone (NQ) Derivatives on Selected Cancer Lines
, 2019
A Novel 1,4-Naphtoquinone-Derived Compound Induces Mitochondria-Mediated Apoptotic Cell Death in Breast Cancer Cells
, 2019
Development of near-infrared region luminescent N-acetyl-L cysteine-coated AgS quantum dots with differential therapeutic effect
, 2019
Key actors in cancer therapy: epigenetic modifiers
, 2019
Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA
, 2018
An Investigation of Anticancer Effects of Doxorubicin and Calcitriol Combination on MCF-7 Cells
, 2018
Chloroquine Used in Combination with Chemotherapy Synergistically Suppresses Growth and Angiogenesis In Vitro and In Vivo
, 2018
Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo
, 2017
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells.
, 2018
Usnea filipendula Induces Apoptosis in Human ColonCancer Cell Lines
, 2018
Pd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino)propane/butane: Synthesis, structure, antiproliferative activity and mechanism of action
, 2018
Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA
, 2018
Palladium(ii) and platinum(ii) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells
, 2018
Palladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells
, 2018
Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA
, 2018
CHLOROQUINE USED COMBINATION WITH CHEMOTHERAPY SYNERGISTICALLY SUPRESSES GROWTH AND ANGIOGENESIS IN VITRO AND IN VIVO
, 2018
Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage.
, 2018
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
, 2018
A PROMISING NATURAL PRODUCT PRISTIMERIN RESULTS IN CYTOTOXICITY AGAINST BREAST CANCER STEM CELLS IN VITRO AND XENOGRAFTS IN VIVO THROUGH APOPTOSIS AN INCOMPLETE AUTHOPHAGY IN BREAST CANCER
, 2018
Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells
, 2017
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
, 2017
A trans platinum II complex induces apoptosis in cancer stem cells of breast cancer
, 2017
Nonapoptotic cell death induced by Hypericum species on cancer cells
, 2017
Nonapoptotic cell death induced by Hypericum species on cancer cells
, 2017
Nonapoptotic cell death induced by Hypericum species oncancer cells
, 2017
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
, 2017
Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells.
, 2017
Synthesis, structures, DNA/protein binding, molecular docking, anticancer activity and ROS generation of Ni(II ), Cu(II) and Zn(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine
, 2017
Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells.
, 2017
Anti-angiogenic effect of a Palladium(II)-Saccharinate Complex of Terpyridine in vitro and in vivo
, 2017
Anti angiogenic effect of a Palladium II Saccharinate Complex of Terpyridine in vitro and in vivo
, 2017
Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents
, 2017
Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents
, 2017
A glance at the methods for detection of apoptosis qualitatively and quantitatively
, 2011
Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine
, 2011
Chemotherapy increases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients
, 2011
The Expressions of pAkt and PTEN in Lung Cancer Patients 24 Hours After the Cisplatin-Based Chemotherapy: A Prospective Pilot Study
, 2011
Circulating Levels of Vascular Endothelial Growth Factor A and Its Soluble Receptor in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease
, 2011
Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate
, 2011
Salivary Gland Tumors
, 2015
Peripherally located A431 cells are more sensitive to cell death induced by exogenous oxidative stress.
, 2012
The effect of melatonin on lipid peroxidation during radiotherapy in female rats
, 1999
Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: a prospective pilot study.
, 2006
Fenretinide induces cytochrome c release caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation
, 2016
Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease
, 2010
Effects of Extremely Low Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain
, 2010
VEGF, VEGF-receptors and lung cancer
, 2007
Molecular signatures of nonalcoholic fatty liver disease: The present and future
, 2010
Cancer of the Eye (Intraocular Cancer)
, 2015
Serum fetuin A/ 2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis
, 2010
Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line
, 2014
Validation data supporting the characterization of novel copper complexes as anticancer agents
, 2016
The ATP assay, but not the MTT assay, detects further cytotoxicity of the combination of anthracyline-based therapy with histone deacetylase inhibitor (Valproic acid) in breast cancer cells
, 2010
Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain
, 2010
Soluble cytokeratin 18 biomarkers may provide information on the type of cell death during early ischemia and reperfusion periods of liver transplantation
, 2010
sFas levels increase in response to cisplatin-based chemotherapy in lung cancer patients
, 2010
Total Phenolic Content, Antioxidant and Cyto-/Genotoxic Activities of Pelargonium quercetorum Agnew in Human Breast Cancer Cells
Utilization of cytokeratin-based biomarkers for pharmacodynamic studies
, 2010
Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents
, 2017
Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetic patients.
, 2010
. Proteomic analysis of serum in patients with nonalcoholic steatohepatitis using MALDI-TOF/MS.
, 2009
Apoptosis-Inducing Effects of Morinda citrifolia L. (Noni) and Doxorubicin on the Ehrlich Ascites (EAC) Tumor in Balb-c Mice
, 2009
Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
, 2017
The role of cell cycle progression for the apoptosis of cancer cells induced by palladium(II)-saccharinate complexes of terpyridine
, 2017
Effect of Mobile Phone Exposure on Apoptotic Glial Cells and Status of Oxidative Stress in Rat Brain
, 2009
Serial changes in circulating M30 antigen, a biomarker of apoptosis, in patients with acute coronary syndromes: relationship with the severity of coronary artery disease
, 2009
Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance
, 2009
Cytotoxic Effect of Conyza canadensis (L.) Cronquist on Human Lung Cancer Cell Lines
, 2016
Apoptosis-inducing Effect of a Palladium(II) Complex-[PdCl(terpy)](sac).2H2O] on Ehrlich Ascites Carcinoma (EAC) in Mice.
, 2016
The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro
, 2016
Olive leaf extract containing oleuropein modulates the cytotoxic effect of epirubicin on breast cancer cells depending on the cell line
, 2016
Ni/Cu/Zn 5,5-diethylbarbiturate complexes with 1,10-phenanthroline and 2,2′-dipyridylamine: synthesis, structures, DNA/BSA binding, nuclease activity, molecular docking, cellular uptake, cytotoxicity and the mode of cell death
, 2016
Pelargonium quercetorum Agnew induces apoptosis without PARP or cytokeratin 18 cleavage in non-small cell lung cancer cell lines.
, 2016
Antigrowth and Apoptosis Inducing Effects of Hypericum Olympicum L. and Hypericum Adenotrichum Spach. on Lung Cancer Cells In Vitro: Involvement of DNA Damage
, 2016
Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro
, 2016
Design, Synthesis, Biological Evaluation, and Antioxidant and Cytotoxic Activity of Heteroatom-Substituted 1,4-Naphtho- and Benzoquinones
, 2015
Cationic Pd(II)/Pt(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine: Synthesis, structures,DNA/BSA interactions, intracellular distribution, cytotoxic activity and induction of apoptosis
, 2015
Anti growth effect of a novel trans dichloridobis 2 2 hydroxyethyl pyridine platinum II complex via induction of apoptosis on breast cancer cell lines
, 2015
Addition of niclosamide to palladium II saccharinate complex of terpyridine results in enhanced cytotoxic activity inducing apoptosis on cancer stem cells of breast cancer
, 2015
In vitro antibacterial activity of sponge-associated fungi against bacterial aquaculture pathogens.
, 2015
The M30 assay does not detect apoptosis in epithelial derived cancer cells expressing low levels of cytokeratin 18
, 2015
IL 6 originated from breast cancer tissue derived mesenchymal stromal cells may contribute to carcinogenesis
, 2015
IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcinogenesis
, 2015
Cytotoxic activity of novel palladium-based compounds on leukemia cell lines
, 2015
Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C.
, 2009
Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease
, 2009
The quest for liver fibrosis biomarkers: Promises from the enhanced liver fibrosis panel and beyond
, 2009
Commentary on the study of Vos et al. "Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease
, 2009
Serum M30 levels: A potential biomarker of severe liver disease in nonalcoholic fatty liver disease and normal aminotransferase levels
, 2009
"A biomarker biopsy” for the diagnosis of NASH: promises from CK-18 fragments
, 2008
Cytokine Gene Polymorphism and Postreperfusion Syndrome During Orthotopic Liver Transplantation
, 2008
The Differential Anticancer Effects of Green Tea in Estrogen Receptor-Positive and Estrogen Receptor-Negative Human Breast Cancer Cell Lines.
, 2008
Anticancer effect of a novel palladium-saccharinate complex of terpyridine by inducing apoptosis on Ehrlich ascites carcinoma (EAC) in Balb-C mice.
, 2015
Clinical significance of activity of ALT enzyme in patients with hepatitis C virus.
, 2007
The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested.
, 2008
Mobile phone exposure does not induce apoptosis on spermatogenesis in rats
, 2008
A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line
, 2015
Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
, 2008
Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress
, 2014
The involvement of IL-10, IL-6, IFN-gamma, TNF-alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients.
, 2008
Soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is decreased in lung cancer patients showing progression: a pilot study.
, 2007
Cancer stem cells: emerging actors in both basic and clinical cancer research
, 2014
Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis.
, 2007
Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro
, 2014
Biochemical and Proteomic Analysis of a Potential Anticancer Agent: Palladium(II) Saccharinate Complex of Terpyridine Acting through Double Strand Break Formation
, 2014
Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent
, 2014
The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival.
, 2007
Higher serum nitrate levels are associated with poor survival in lung cancer patients.
, 2006
Genotoxic, cytotoxic, and apoptotic effects of crude extract of Usnea filipendula Stirt. in vitro
, 2014
Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: a prospective pilot study.
, 2006
Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in vitro and in vivo
, 2014
Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells
, 2014
Investigation of fecal pancreatic elastase-1 levels in type 2 diabetic patients.
, 2005
Can safe and long-term exposure to extremely low frequency (50 Hz) magnetic fields affect apoptosis, reproduction, and oxidative stress?
, 2013
Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro
, 2013
Differential Cytotoxic Activity of a Novel Palladium-Based Compound on Prostate Cell Lines, Primary Prostate Epithelial Cells and Prostate Stem Cells
, 2013
Palladium(II) saccharinate complexes with bis(2-pyridylmethyl)amine induce cell death by apoptosis in human breast cancer cells in vitro
, 2013
Synthesis structural characterization and cell death inducing effect of novel palladium II and platinum II saccharinate complexes with 2 hydroxymethyl pyridine and 2 2 hydroxyethyl pyridine on cancer cells in vitro
, 2013
Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro
, 2013
Synthesis crystal structures DNA binding and cytotoxicity of two novel platinum II complexes containing 2 hydroxymethyl pyridine and pyridine 2 carboxylate ligands
, 2013
Effects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal women.
, 2005
Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands
, 2013
Changes in Gene Methylation Following Chemotherapyin Breast Cancer Cell Lines
, 2013
Cytokine gene polymorphism and early graft rejection in liver transplant recipients.
, 2004
trans Dichloridopalladium II and platinum II complexes with 2 hydroxymethyl pyridine and 2 2 hydroxyethyl pyridine Synthesis structural characterization DNA binding and in vitro cytotoxicity studies
, 2013
Evaluation of the effects of helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: a prospective, sixth-month follow-up study.
, 2004
Genotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells
, 2014
Isolation of Major Phenolic Compounds from the Extracts of Prunella L. Species Grown in Turkey and Their Antioxidant and Cytotoxic Activities
, 2014
Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay
, 2004
Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation
, 2003
4-(N-Hydroxyphenyl)retinamide can Selectively Induces Apoptosis in Human Epidermoid Carcinoma Cells but not in Normal Dermal Fibroblasts.
, 2001
Fenretinide and Its Relation to Cancer
, 1999
Toward a Biochemical Diagnosis of NASH: Insights From Pathophysiology For Distinguishing Simple Steatosis From Steatohepatitis
, 2011
The effect of melatonin on lipid peroxidation during radiotherapy in female rats
, 1999
Cell death inducing effect of novel palladium II and platinum II complexes on non small cell lung cancer cells in vitro
, 2011
Anti cancer activity of a novel palladium II complex on human breast cancer cells in vitro and in vivo
, 2011
Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo
, 2011
Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro
, 2011
General Practitioners' Opinions about the Basic Sciences in Relation to Medicine
, 1995
Apoptosis: why and how does it occur in biology?
, 2011
Differential Cytotoxic Activity of a Novel Palladium Based Compound on Prostate Cell Lines Primary Prostate Epithelial Cells and Prostate Stem Cells
, 2013
The levels of caspase cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival
, 2016
Interference by Anti Cancer Chemotherapeutic Agents in the MTT Tumor Chemosensitivity Assay
, 2004
A proteomic analysis of p53 independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line
, 2015
Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis
, 2007
The p53 independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib
, 2012
The involvement of IL 10 IL 6 IFN gamma TNF alpha and TGF beta gene polymorphisms among Turkish lung cancer patients
, 2016
The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested
, 2016
Promising anticancer activity of a lichen Parmelia sulcata Taylor against breast cancer cell lines and genotoxic effect on human lymphocytes
, 2015
Bildiriler
Cytotoxic/Apoptotic effects of the benzofuran-substituted chalcone derivatives in colon cancer. - Erkısa Merve,Pınar Alper,COŞKUN DEMET,ULUKAYA ENGİN,ARI FERDA
The Plant-Derived Triterpenoid Pristimerin is a Potent Anticancer Agent Due to Its Cytotoxic Activity on Breast Cancer in vitro and in vivo - CEVATEMRE BUSE,Erkısa Merve,AZTOPAL NAZLIHAN,KARAKAŞ DİDEM,Pınar Alper,Tsimplouli Chrisiida,Sereti Evangelia,Dimas Konstantinos,Armutak Elif I Ikitimur,Gurevin Ebru Gurel,Uvez Ayça,Mori Mattia,Berardozzi Simone,Ingallina Cinzia,Botta Bruno,ULUKAYA ENGİN
Özgün bir palladyum-barbitürat bileşiğinin anti-kanser ilaç adayı olarak preklinik analizi - DURMUS SELVI,UNAL OZLEM,SAVALAN ALTAY,ICSEL CEYDA,YILMAZ VEYSEL TURAN,VAN TELLINGTON OLAF,YAĞCI ACAR HAVVA,SHAHIN OZGUR,ULUKAYA ENGİN
Combination Therapy with Valproic Acid and Cu (II)- Barbiturate Complex Induces ROS-Mediated Apoptosis in Breast Cancer Stem Cell - ERKISA MERVE, AZTOPAL NAZLIHAN, ERTÜRK ELİF, ULUKAYA ENGİN, ARI FERDA
Paklitaksel Tedavisinin Meme Kanseri Kanser Kök Hücrelerinde miRNA Ekspresyon Profiline Etkisi - ERTÜRK ELİF, AKGÜN OĞUZHAN, ERKISA MERVE, AZTOPAL NAZLIHAN, ULUKAYA ENGİN, ZEYBEK ŞAKİR ÜMİT, KÜÇÜKALİ CEM İSMAİL, ARI FERDA
Palladıum Incorporated Mıcelle: A Promısıng Materıal For Future Non-Small Cell Lung Cancer - Erkısa Merve,BÜYÜKKÖROĞLU GÜLAY,ŞENEL BEHİYE,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN,ARI FERDA
Chloroquine improves the anticancer effectsof doxorubicin in vitro and in vivo models on Mouse Mammary Tumor Ehrlich ascites carcinoma (EAC) - AYDINLIK ŞEYMA,ARMUTAK ELİF İLKAY,ÜVEZ AYÇA,ARI FERDA,SÖNMEZ KIVILCIM,ESENER OSMAN BEHZAT BURAK,ÜSTÜN ALKAN FULYA,AKTAŞ ABİT,ZEYBEK ŞAKİR ÜMİT,ULUKAYA ENGİN,DİMAS KONSTANTINOS,GÜREL GÜREVİN EBRU
Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism - AYDINLIK ŞEYMA,ÜVEZ AYÇA,ARMUTAK ELİF İLKAY,DERE EGEMEN,ULUKAYA ENGİN
Cytotoxic Activites of 3-bromo-5-chloro-2-hydroxyacetophenone-N-phenyl-thiosemicarbazone and 3-bromo-5-chloro-2-hydroxy-acetophenone-N-phenylthiosemicarbazidato triphenylphosphine Nickel(II) Complex Against MCF-7 (Cancer) - BAL DEMİRCİ TÜLAY,GÜVELİ ŞÜKRİYE,KARAKAŞ DİDEM,ULUKAYA ENGİN,ÜLKÜSEVEN BAHRİ
Thiosemicarbazone and Nickel(II) Complex Activites Against DU145 Cells - BAL DEMİRCİ TÜLAY,GÜVELİ ŞÜKRİYE,KARAKAŞ DİDEM,ULUKAYA ENGİN,ÜLKÜSEVEN BAHRİ
The cytotoxic activities of substitue-salicylaldehyde-S-methyl-thiosemicarbazone and it’s complex against MCF-7 cell line - GÜVELİ ŞÜKRİYE,BAL DEMİRCİ TÜLAY,KARAKAŞ DİDEM,ULUKAYA ENGİN,ÜLKÜSEVEN BAHRİ
N-Substituted Thiosemicarbazones - Synthesis,Characterization and Comparison of Cytotoxicities Against MCF 7 Cell - GÜVELİ ŞÜKRİYE,KARAKAŞ DİDEM,ULUKAYA ENGİN,ÜLKÜSEVEN BAHRİ,BAL DEMİRCİ TÜLAY
TARGETING BREAST CANCER STEM CELLS VIA DUALINHIBITION OF WNT SIGNALING AND HISTONE DEACETYLATION - AZTOPAL NAZLIHAN,ERKISA MERVE,ARI FERDA,DERE EGEMEN,ULUKAYA ENGİN
Benzofuran İçeren Yeni Kalkon Bileşiklerinin Kolon Kanseri Üzerine olan Sitotoksik/Apoptotik Etkilerinin İncelenmesi - Erkısa Merve,Pınar Alper,COŞKUN DEMET,ULUKAYA ENGİN,ARI FERDA
The Other Faces of Death: Cell Type Dependent Apoptotic Effects of Dinuclear Pd (II) Compound - Erkısa Merve,YILMAZTEPE ORAL ARZU,ULUKAYA ENGİN,ŞENGÜL ABDURRAHMAN
Dual inhibition of Wnt/beta-catenin signaling and histone deacetylation as a new strategy to eliminate breast cancer stem cells by augmentation of apoptosis - AZTOPAL NAZLIHAN,Merve Erkısa,ARI FERDA,DERE EGEMEN,ULUKAYA ENGİN
Türkiye’de Yetişen Chrysophthalmum Schultz Bıp. Türleri Üzerinde Farmakognozik Araştırmalar - AYAZ FATMA,KÜÇÜKBOYACI NURGÜN,Gören Nezhun,ÇALIŞ İHSAN,Aydınlık Şeyma,ULUKAYA ENGİN,DUMAN HAYRİ,BANİ BARIŞ,Yousuf Sammer,Choudhary Muhammad Iqbal
The anti-angiogenic effect of the Palladium(ll) Complex-[PdCI(terpy)](sac).2H20] on HUVECs tube formation and in vivo CAM assay - ÜVEZ AYÇA,AYDINLIK ŞEYMA,KIYAN HÜLYA TUBA,GÜREL GÜREVİN EBRU,ULUKAYA ENGİN,YILMAZ VEYSEL TURAN,ARMUTAK ELİF İLKAY
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF SOME NEW MANNICH BASES DERIVED FROM 1,2,4-TRIAZOLES - Avcı Ahmet,Taşçı Hayrünnisa,GÖKHAN KELEKÇİ NESRİN,AZTOPAL NAZLIHAN,ULUKAYA ENGİN,TOZKOPARAN BİRSEN
INVESTIGATION OF ANTI-CANCER ACTIVITY OF ADANSONIADIGITATA (BAOBAB) IN DIFFERENT CANCER CELLS - Zorlı Kemal,Sagna Nadia Reymonde Emma,ARI FERDA,akgün oğuzhan,ULUKAYA ENGİN,ÇELİKLER KASIMOĞULLARI SERAP
Cytotoxıc Effect of Dıfferent Extracts of Salvıa Candıdıssıma Vahl. Ssp.candıdıssıma on Lung Cancer Cells. - Alioğlu İmren,ÇELİKLER KASIMOĞULLARI SERAP,Akgün Oğuzhan,ÇEBİ AYŞEGÜL,ULUKAYA ENGİN,ARI FERDA
Palladium Incorporated Micelle: A Promising Material for Future Non-Small Cell Lung Cancer. - Erkısa Merve,BÜYÜKKÖROĞLU GÜLAY,ŞENEL BEHİYE,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN,ARI FERDA
Palladium nanoparticles selectively ınduce apoptosis in lung cancer cells through reactive oxygen species. - Erkısa Merve,BÜYÜKKÖROĞLU GÜLAY,ŞENEL BEHİYE,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN,ARI FERDA
N-Substituted Thiosemicarbazones-Synthesis, Characterization and Comparison of Cytotoxicities Against MCF 7 Cell - GÜVELİ ŞÜKRİYE,KARAKAŞ DİDEM,ULUKAYA ENGİN,ÜLKÜSEVEN BAHRİ,BAL DEMİRCİ TÜLAY
CYTOTOXIC EFFECT OF DIFFERENT EXTRACTS OF SALVIACANDIDISSIMA VAHL. SSP. CANDIDISSIMA ON LUNG CANCERCELLS - Alioglu İmren,ÇELİKLER KASIMOĞULLARI SERAP,akgün oğuzhan,ÇEBİ AYŞEGÜL,ULUKAYA ENGİN,ARI FERDA
Chloroquine improves the anticancer effects of doxorubicin in vitro and in vivo models on Mouse Mammary Tumor Ehrlich ascites carcinoma (EAC) - AYDINLIK ŞEYMA,ARMUTAK ELİF İLKAY,UVEZ AYÇA,ARI FERDA,SÖNMEZ KIVILCIM,ESENER OSMAN BEHZAT BURAK,ÜSTÜN ALKAN FULYA,AKTAŞ ABİT,ZEYBEK ŞAKİR ÜMİT,ULUKAYA ENGİN,KONSTANTINOS DIMAS,GÜREL GÜREVİN EBRU
Investigation of Anti-Cancer Activity of Adansonia digitata (Baobab) In Different Cancer Cells. - Zorli Kemal,Nadia Raymonde Emma Sagna,ARI FERDA,Akgün Oğuzhan,ULUKAYA ENGİN,ÇELİKLER KASIMOĞULLARI SERAP
Reversal of Unresponsive Lung Cancer Cases Treated on the Basis of an Ex Vivo Tumor Chemosensitivity Assay (Onkogram®). - ULUKAYA ENGİN,Pınar Alper,Karakaş Didem,Erkısa Merve,DELİGÖNÜL ADEM,ARI FERDA,KURT ENDER
PALLADIUM INCORPORATED MICELLE: A PROMISING MATERIAL FOR FUTURE NON-SMALL CELL LUNG CANCER - ERKISA MERVE,BÜYÜKKÖROĞLU GÜLAY,ŞENEL BEHİYE,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN,ARI FERDA
Computer-Aided Prediction and Experimental Evaluation of Dithiocarbamates of 9,10-Anthracenedione as New Anticancer Agents - STASEVYCH MARYNA V,ZVARYCH VİKTOR I,LUNİN VOLODYMYR V,DENİZ NAHİDE GÜLŞAH,GÖKMEN ZELİHA,AKGÜN OĞUZHAN,ULUKAYA ENGİN,VOLODYMYR P NOVIKOV,GLORIOZOVA TATYANA A,POROIKOV VLADIMIR V
Mammospheres Cancer Stem Cell Enriched Population in Breast Cancer Show Resistance Against A Palladium II Saccharinate Complex of Terpyridine - karakas didem,CEVATEMRE BUSE,aztopal nazlihan,YILMAZ VEYSEL TURAN,ULUKAYA ENGİN
Palladium II Based Novel Approach to Kill Cancer Stem Cells of Breast Cancer - ULUKAYA ENGİN,aydinlik seyma,erkisa merve,ARI FERDA,YILMAZ VEYSEL TURAN
Inhibition of sonic hedgehog pathway in breast cancer stem cells does not provide extra benefit in cytotoxicity resulted from Pd II saccharinate complex of terpyridine - ULUKAYA ENGİN,CEVATEMRE BUSE,karakas didem,aztopal nazlihan,icsel ceyda
Palladium II based anticancer compounds A new hope or an illusion - ULUKAYA ENGİN