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Academic Member

Prof. Hikmet Koçak

Temel Tıp
Prof. Koçak was born in 1968, in Ankara. Between 1991-2000, she received her master and doctorate degrees from Istanbul University, Istanbul Faculty of Medicine, Department of Biochemistry. She became an Associate Professor of Biochemistry in 2006 and Professor in 2012. She worked as a staff member at Demiroğlu Bilim University Faculty of Medicine, Department of Biochemistry between 2008-2019. During these years at Demiroğlu Bilim University, she was assigned as the ‘head of Biochemistry Department’, ‘board member of the technology transfer Office, Faculty of Health Sciences, Institute of Heal...
Prof. Koçak was born in 1968, in Ankara. Between 1991-2000, she received her master and doctorate degrees from Istanbul University, Istanbul Faculty of Medicine, Department of Biochemistry. She became an Associate Professor of Biochemistry in 2006 and Professor in 2012. She worked as a staff member at Demiroğlu Bilim University Faculty of Medicine, Department of Biochemistry between 2008-2019. During these years at Demiroğlu Bilim University, she was assigned as the ‘head of Biochemistry Department’, ‘board member of the technology transfer Office, Faculty of Health Sciences, Institute of Health Sciences and the Vocational School of Health Services’ and had ‘commission membership for Student Transfers’ for Undergraduate Programs. In addition to these, during the Integrated System Structuring Process of the Faculty of Medicine, she worked as a coordinator, assistant coordinator and as a member of educational and administrative positions in many boards and commissions. Between 2008 and 2018, she worked as a member of the board of trustees of İstanbul Section of Turkish Biochemistry Association and Scientific Activity Organization Committee. She started to work at Istinye University Faculty of Medicine, Department of Medical Education in 2019. Prof. Koçak has 32 international published papers in Science Citation Index (SCI) and SCI-Exp journals, 4 published articles in national refereed journals, 17 international and 27 national presentations/posters presented at congress symposiums, and has 15 research projects. She was awarded in national scientific congresses with her three studies in 2004, 2013 and 2014 respectively. Her 32 published articles in international journals have 613 citations when searched in "Google Scholar Citations", According to the Web of Science ResearcherID, her h-index is 14.

Articles

  • The effect of dietary curcumin on hepatic chymase activity and serum fetuin-A levels in rats fed on a high-fat diet ,2017
  • Capsaicin Modulates Adipocyte Cell Differentiation and Inflammatory Gene Expression ,2024
  • Which Pathology Education Method Is More Useful in Active Professional Life? A Survey of Clinicians ,2022
  • Temel Tıp Döneminde Alınan Patoloji Eğitimi Klinik Eğitim Döneminde Yarar Sağlıyor mu? 5. Sınıf Tıp Öğrencilerinde Yapılan Bir Anket Çalışması ,2022
  • Dietary curcumin and capsaicin: Relationship with hepaticoxidative stress and apoptosis in rats fed a high fat diet ,2019
  • KURKUMİN UYGULAMASININ YÜKSEK YAĞLI DİYETLE BESLENEN SIÇANLARIN TESTİS DOKUSUNDA OKSİDANANTİOKSİDAN SİSTEM ÜZERİNE ETKİSİ ,2020
  • Serum chymase levels in obese individuals: the relationship with inflammation and hypertension ,2020
  • Dietary curcumin and capsaicin: Relationship with hepaticoxidative stress and apoptosis in rats fed a high fat diet ,2019
  • ROLE OF DIETARY CURCUMIN AND CAPSAICIN ON TESTICULAR AND HEPATIC OXIDANT-ANTIOXIDANT STATUS IN RATS FED A HIGH FED DIET ,2019
  • The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet ,2016
  • Serum fetuin-A and arginase-1 in human obesity model: Is there any interaction between inflammatory status and arginine metabolism? ,2015
  • Effect of curcumin on hepatic heme oxygenase 1 expression in high fat diet fed rats: is there a triangular relationship? ,2014
  • The effect of dietary curcumin on hepatic chymase activity and serum fetuin-A levels in rats fed on a high-fat diet ,2017
  • The effect of dietary curcumin on hepatic chymase activity and serum fetuin-A levels in rats fed on a high-fat diet ,2017
  • Curcumin prevents liver fat accumulation and serum fetuin A increase in rats fed a high fat diet ,2013
  • Indices of Oxidative Stress in Eutopic and Ectopic Endometrium of Women with Endometriosis ,2004
  • The Evaluation of C reaktive Protein Homocysteine and Vitamin B6 Concentrations in Behçet and Rheumatoid Arthritis Disease ,2003
  • Effect of exogenous melatonin on ethanol induced changes in Na K and Ca 2 ATPase activities in rat synaptosomes ,2002
  • Comparison of the activities of Na K ATPase in brains of rats at different ages ,2002
  • The effect of Aminoguanidine on Diabetes Induced Inactivation of Kidney Na K ATPase in Rats ,2001
  • Evaluation of Leukocyte Arylsulfatase A Activity in Patients With Breast Cancer and Benign Breast Disease ,2001
  • Sex dependent changes in blood brain barrier permeability and brain Na K ATPase activity in rats following acute water intoxication ,2000
  • Effects of streptozotocin induced diabetes and pentylenetetrazol induced seizure on brain cortex Ca2 ATPase activity in rats ,2000
  • Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine treated diabetic rats ,2000
  • Brain cortex Na K ATPase activities in streptozotocin diabetic and pentyleneterazol epileptic rats ,1997
  • Serum prolidase I activity and some bone metabolic markers in patients with breast cancer in relation to menopausal status ,2003
  • Acute Phase Reactants in Allergic Airway Disease ,2004
  • Determination of diagnostic and prognostic values of urinary interleukin 8 tumor necrosis factor and leukocyte arylsulfatase A activity in patients with bladder cancer ,2004
  • Urine 8 isoprostane F2 concentrations in patients with neurogenic bladder due to spinal cord injury ,2004
  • The relation between serum MDA and cystatin C levels in chronic spinal cord injury patients ,2005
  • Evaluation of Leukocyte Arylsulphatase A Serum Interleukin 6 and Urinary Heparan Sulphate Following Tamoxifen Therapy in Breast Cancer ,2005
  • Circulating ghrelin levels in obese women a possible association with hypertension ,2007
  • Early and Late Effects of Hyperbaric Oxygen Treatment on Oxidative Stress Parameters in Diabetic Patients ,2008
  • Collagen synthesis nitric oxide and asymmetric dimethylarginine in diabetic subjects undergoing hyperbaric oxygen therapy ,2010
  • Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women ,2011
  • Sağlıklı insanlarda eritrosit membranı Na K ATPaz ve Ca2 ATPaz aktivitelerine ve sialik asid düzeylerine yaşlanmanın etkisi ,1999
  • Kardiovasküler hastalıkların klinik tanısında serum İnterlökin 6 ve Tümör Nekroz Faktör düzeylerinin önemi ,2000
  • Seminal plazma superoksid dismutaz ve total antioksidan düzeylerinin erkek infertilesine etkileri ,2003
  • Urinary Nerve Growth Factor in Children with Overactive Bladder A Promising Noninvasive and Objective Biomarker ,2013
  • Appetite regulating Hormones in Chronic Kidney Disease Patients ,2011
  • Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis ,2009
  • Advanced oxidation protein products in obese women its relation to insulin resistance and resistin ,2007
  • Cystatin C and creatinine as indices of glomerular filtration rate in the immediate follow up of renal transplant patients ,2005
  • Endometriosisli olguların ötopik ve ektopik endometrium dokusunda oksidatif hasar göstergeleri ,2003

Reports

  • Effects of Curcumin on Oxidant-Antioxidant System in High Fat Diet Fed Rats - TANRIKULU KÜÇÜK SEVDA,KÜÇÜKGERGİN CANAN,DOĞRU ABBASOĞLU SEMRA,KOÇAK HİKMET,SEYİTHANOĞLU MUHAMMED,ÖNER İYİDOĞAN YILDIZ
  • The Effects of Curcumin and Capsaicin on Liver DNA Fragmentation and Total Antioxidant Status in a High-Fat-Diet Model - KOÇAK HİKMET,SÖĞÜT İBRAHİM,TANRIKULU KÜÇÜK SEVDA,SEYİTHANOĞLU MUHAMMED,TUNÇDEMİR MATEM,ÖNER İYİDOĞAN YILDIZ
  • The Effects of Dietary Curcumin and Capsaicin on Preventing High Fat Diet Induced Fatty Liver from Apoptosis in a Rat Model - ÖNER İYİDOĞAN YILDIZ,TANRIKULU KÜÇÜK SEVDA,KÜÇÜKGERGİN CANAN,SÖĞÜT İBRAHİM,DOĞRU ABBASOĞLU SEMRA,SEYİTHANOĞLU MUHAMMED,KOÇAK HİKMET
  • KURKUMİN VE KAPSAİSİN UYGULAMASININ YÜKSEK YAĞLI DİYETLE BESLENEN SIÇANLARDA KARACİĞER İLERİOKSİDASYON ÜRÜNLERİNE ETKİSİ - SEYİTHANOĞLU MUHAMMED,TANRIKULU KÜÇÜK SEVDA,KÜÇÜKGERGİN CANAN,KOÇAK HİKMET,ÖNER İYİDOĞAN YILDIZ
  • Vısual and Automated Detectıon of Mıld Hemolysıs in Serum Samples. - GUN ATAK Palmet,İnan Nese,Görmüş Uzay,TANRIKULU KÜÇÜK SEVDA,KOÇAK HİKMET
  • The Effect Of Curcumin And Capsaicin Supplementation On Fetuin-A Expression And Hepatic Fat Accumulation In High Fat Diet Fed Rats. - İYİDOĞAN YILDIZ,Seyithanoğlu Muhammet,Doğru Abbasoğlu Semra,TANRIKULU KÜÇÜK SEVDA,KOÇAK HİKMET,Beyhan Ozdas Sule,YAPIŞLAR HANDE,Kocak Toker Necla
  • The Effects of Curcumin and Capsaicin on LiverDNA Fragmentation and Total Antioxidant Statusin a High-Fat-Diet Model. - KOÇAK HİKMET,SÖĞÜT İBRAHİM,TANRIKULU KÜÇÜK SEVDA,SEYİTHANOĞLU MUHAMMED,TUNÇDEMİR MATEM,İYİDOĞAN YILDIZ
  • Kurkumin ve Kapsaisin Uygulamasının Yüksek Yağlı Diyetle Beslenen Sıçanlarda Karaciğer İleri Oksidasyon Ürünlerine Etkisi - SEYİTHANOĞLU MUHAMMED,TANRIKULU KÜÇÜK SEVDA,Küçükgergin Canan,KOÇAK HİKMET,İYİDOĞAN YILDIZ
  • The Effects of Dietary Curcumin and Capsaicin on Preventing High Fat Diet Induced Fatty Liver from Apoptosis in a Rat Model - İYİDOĞAN YILDIZ,TANRIKULU KÜÇÜK SEVDA,Küçükgergin Canan,SÖĞÜT İBRAHİM,ABBASOĞLU SEMRA,SEYİTHANOĞLU MUHAMMED,KOÇAK HİKMET
  • The Effects of Curcumin and Capsaicin on Liver DNA Fragmentation and Total Antioxidant Status in a High-Fat-Diet Model - KOÇAK HİKMET,SÖĞÜT İBRAHİM,TANRIKULU KÜÇÜK SEVDA,SEYİTHANOĞLU MUHAMMED,TUNÇDEMİR MATEM,İYİDOĞAN YILDIZ
  • Effects of Curcumin on Oxidant-Antioxidant System in High Fat Diet Fed Rats - TANRIKULU KÜÇÜK SEVDA,Küçükgergin Canan,ABBASOĞLU SEMRA,KOÇAK HİKMET,SEYİTHANOĞLU MUHAMMED,İYİDOĞAN YILDIZ
  • Effects of Curcumin Intake on Fatty Liver in High Fat Diet Fed Rats - TanrıkuluKucuk Sevda, Seyidhanoglu Muhammed, OnerIyidogan Yıldız, Kocak Hikmet, DogruAbbasoglu Semra, Aydın Abdurrahman Fatih, KocakToker Necla
  • Obezitede Serum Fetuin A ve ADMA Düzeylerinin Hipertansiyon ile İlişkisi - Seyithanoğlu Muhammed, TanrıkuluKüçük Sevda, Kocak Hikmet, İyidoğan Yıldız, KayanTapan Tuba
  • Curcumin Uygulamasının Yüksek Yağli Diyetle Beslenen Sıçanlarda Karaciğer Yağlanması ve Oksidatif Stres Üzerine Etkisi - Seyithanoğlu Muhammet, İyidoğan Yıldız, Kocak Hikmet, Tanrıkulu Küçük Sevda
  • Yüksek Yağli Diyetle Beslenen Farelerin Karaciğerinde Trigliserid Düzeyleri ve Oksidatif Stres Üzerine Enginar Yapraği Ekstresinin Etkisi - Seyithanoğlu Muhammet, İyidoğan Yıldız, Kocak Hikmet, Kocak Toker Necla, Uysal Müjdat
  • Deneysel Obezite Modelinde Oral Curcumin Uygulamasının Karaciğer Trigliserid Düzeyleri ve Oksidatif Stres Üzerine Etkisi - Seyithanoğlu Muhammet, İyidoğan Yıldız, Kocak Hikmet, Koçak Toker Necla, Uysal Müjdat
  • İdrar NGF düzeyleri aşırı aktif mesanesi olan çocuk hastalarda tanı ve tedavi sürecinde gelecekvaat eden noninvaziv bir biomarker olabilir mi - Seyithanoğlu Muhammet, Kocak Hikmet, İyidoğan Yıldız, Oktar Tayfun, Erdem S, Kocak Taner
  • Hiperbarik oksijenin serum PINP PIIINP düzeylerine ve prolidaz aktivitesine etkisi - Gürdöl Figen, Cimşit Maide, Öner İyidoğan Yıldız, Şengün Şermin, Yalçınkaya Seda, Koçak Hikmet
  • Diyabetik obezlerde AOPP düzeylerinin insülin direnci ve proinflamatuvar sitokinlerle bağıntısı - Önerİyidoğan Yıldız, Koçak Hikmet, Gürdöl Figen, Öner Pernur, Süzme Rafi, Esin Deniz, İşsever Halim
  • Serum grelin ve leptin düzeylerinin kan basıncı ve vücut kütle indeksi ile bağıntısı - Önerİyidoğan Yıldız, Koçak Hikmet, Gürdöl Figen, Öner Pernur, Esin Deniz
  • Obezitede serum Rezistin ve sitokin düeyleri ile Tip 2 Diabet İlişkisinin İncelenmesi - Önerİyidoğan Yıldız, Koçak Hikmet, Gürdöl Figen, Öner Pernur, Süzme Rafi, Esin Deniz
  • Spinal Kord Travmalı Hastalarda Serum Malondialdehit Düzeyleri ve Sistatin C Arasındaki İlişki - Koçak Hikmet, Öner İyidoğan Yıldız, Gürdöl Figen, Koçak Taner, Esin Deniz
  • Lökosit Arilsülfataz A aktiviteleri ile serum İnterlökin 6 ve idrar heparan sülfat düzeylerinin meme kanserli hastalarda tanısal önemi ve tedavi ile ilişkileri - Öner İyidoğan Yıldız, Öner Pernur, Koçak Hikmet, Lama Abdül, Bekpınar Selda, Gürdöl Figen, Unur Nurettin, Kır Özbek Zeynep
  • Behçet ve romatoid artrit hastalarında C reaktif protein homosistein ve B6 vitamin düzeylerinin değerlendirilmesi - Bekpınar Selda, Koçak Hikmet, Ünlüçerçi Yeşim, Genç Sema, Akdağ Köse Ayfer, Göğüş Feride
  • Nörojen mesaneli hastalarda 8 epi PGF2a düzeylerinin prognostik değeri ve antioksidan statüsle ilişkisi - Önerİyidoğan Yıldız, Koçak Hikmet, Gürdöl Figen, Gürdöl Figen, Koçak Taner, Erol Bülent
  • Seminal plazma superoksid dismutaz ve total antioksidan düzeylerinin erkek infertilesine etkileri - Önerİyidoğan Yıldız, Genç Sema, Koçak Hikmet, Akkuş Emre
  • Renal transplantansyon takibinde sistatin C nin güvenilirliği ve olası graft disfonksiyonun tespitinde CRP ve SAA nın rolü - Koçak Hikmet, Önerİyidoğan Yıldız, Koçak Taner, Nane İsmet
  • Endometriosisli olguların ötopik ve ektopik endometrium dokusunda oksidatif hasar göstergeleri - Önerİyidoğan Yıldız, Koçak Hikmet, Gürdöl Figen, Korkmaz Düzgün, Buyru Faruk
  • Sıçan sinaptozomlarında Na K ATPaz ve Ca2 ATPaz aktivitelerinde alkole bağlı değişiklikler üzerine eksojen melatoninin etkisi - Öner Pernur, Koçak Hikmet, Gürdöl Figen, Çınar Fisun
  • Eksojen melatonin verilmiş sıçanlarda sinaptozomal Na K ATPaz Ca2 ATPaz ve asetilkolinesteraz aktivitelerinde yaşla ilişkili değişiklikler - Koçak Hikmet, Öner Pernur
  • Hipoosmolaritenin dişi ve erkek sıçanların beyin dokusu Na K ATPaz enzimi üzerine etkileri - Koçak Hikmet, Öztaş Baria, Öner Pernur
  • Kardiovasküler hastalıkların klinik tanısında serum İnterlökin 6 ve Tümör Nekroz Faktör düzeylerinin önemi - Genç Sema, Koçak Hikmet, Figen Gürdöl, Salmayenli Nihal, Güler Kerem, Keleş İbrahim
  • Diabetik ve epileptik sıçanlarda beyin korteksi Ca2 ATPaz aktiviteleri - Koçak Hikmet, Öner Pernur, Öztaş Baria
  • Sağlıklı insanlarda eritrosit membranı Na K ATPaz ve Ca2 ATPaz aktivitelerine ve sialik asid düzeylerine yaşlanmanın etkisi - Koçak Hikmet, Öner Pernur
  • Diabetik ve konvülziyonların beyin korteksi Na K ATPaz enzim aktivitesine etkisi - Koçak Hikmet, Öner Pernur, Öztaş Baria
  • Effects of Curcumin Supplementation on Serum Fetuin A Levels in Rats Fed A High Fat Diet Is Curcumin Useful for Treatment of Fatty Liver Disease - Öner İyidoğan Yıldız, Koçak Hikmet, Seyidhanoğlu Muhammet, Gurdol Figen, Gülçubuk Ahmet, Yıldırım F, Cevik Aydın, Uysal Müjdat
  • Effects of Curcumın Supplementatıon on Lıver Metabolısm in Rats Fed A Hıgh Fat Dıet A Proteomıc Approach - Koçak Hikmet, Öner İyidoğan Yıldız, Baykal Ahmet Tarık, Seyidhanoglu Muhammet, Cevik Aydın, Gurdol Figen, Uysal Müjdat
  • Urinary Nerve Growth Factor Levels in Children with Non Neuropathic Overactive Bladder A Promising Biomarker - Oktar Tayfun, Koçak Taner, Koçak Hikmet, İyidoğan Yıldız, Erdem S, Ziylan Orhan
  • Plasma acylated ghrelin obestatin and leptin in different stages of chronic kidney disease patients - Önerİyidoğan Yıldız, Öner Pernur, Gürdöl Figen, Koçak Hikmet, ÇetinalpDemircan Pınar, Çalışkan Yaşar, Kocak Taner, Türkmen Aydın
  • The Relation of Dimethylarginines With İnflammation and Oxidative Stress Markers in Patients With Chronic Renal Failure - Öner Pernur, İyidoğan Öner Yıldız, Koçak Hikmet, Gürdöl Figen, Bekpınar Selda, Ünlüçerçi Yeşim, Çalışkan Yaşar, Türkmen Aydın, Koçak Taner, Çetinalp Demircan Pınar
  • Serum Ghrelın Adıponectın Asymmetric Dimethylarginine Adma And Nitric Oxide Levels In Postmenopausal Obese Women - Koçak Hikmet, Öner İyidoğan Yıldız, Gürdöl Figen, Öner Pernur, Esin Deniz
  • Changes in factors involved in wound healing during hyperbaric oxygen therapy Biomarkers of collagen synthesis nitric oxide and asymmetric dimethylarginine - Öner İyidoğan Yıldız, Cimşit Maide, Gürdöl Figen, Koçak Hikmet, Şengün Şermin, Yalçınkaya Seda
  • Clinical evaluation of leukocyte Arylsulfatase A serum interleukin 6 and urinary heparan sulphate estimations in breast cancer patients and their relationship to the tamoxifen treatment - Öner Pernur, Öner İyidoğan Yıldız, Koçak Hikmet, Lama Abdül, Bekpınar Selda, Gürdöl Figen, Unur Nurettin, Özbek Kır Zeynep
  • The effect of aminoguanidine on NOS activity in gastric mucosal damage in rats - Ünlüçerçi Yeşim, Koçak Hikmet, Kuntsal Leyla, Baysal Kemal, Bekpınar Selda
  • The effect of aminoguanidine on NOS activity in gastric mucosal damage in rats - Ünlüçerçi Yeşim, Koçak Hikmet, Kuntsal Leyla, Baysal Kemal, Bekpınar Selda
  • Comparison of the effects of streptozotocin induced diabetes and pentylenetetrazol induced seizure on brain cortex Ca2 ATPase activity - Koçak Hikmet, Öner Pernur, Öztaş Baria

Awards

  • Kongre Ödülü – 2014
  • Uluslararası Katılımlı Kongre Lab Expo 2013 – 2013
  • 18. Ulusal Biyokimya Kongresi – 2004
Prof. Hikmet Koçak - İstinye Üniversitesi
hikmet.kocakistinye.edu.tr
SW

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