Assistant Professor Esma Nur Zeydanli

Dr. Esma Nur Zeydanlı, Assistant Professor, graduated as the highest-ranking student from the Department of Biology at Gazi University in 2006. She continued her postgraduate education in the Department of Biophysics, Faculty of Medicine, Ankara University, where her master’s studies were supported by TÜBITAK (BIDEP 2228A). In 2009, she was appointed as a Research Assistant (Article 33a) in the same department and continued her doctoral studies. After completing her PhD in 2015, she pursued her academic career as a faculty member at Sivas Cumhuriyet Universit...

Dr. Esma Nur Zeydanlı, Assistant Professor, graduated as the highest-ranking student from the Department of Biology at Gazi University in 2006. She continued her postgraduate education in the Department of Biophysics, Faculty of Medicine, Ankara University, where her master’s studies were supported by TÜBITAK (BIDEP 2228A). In 2009, she was appointed as a Research Assistant (Article 33a) in the same department and continued her doctoral studies. After completing her PhD in 2015, she pursued her academic career as a faculty member at Sivas Cumhuriyet University.

She accomplished administrative duties at the Cumhuriyet University Faculty of Medicine Research Center (Deputy Director) and the Advanced Technology Research and Application Center (Responsible for the Western blot system), where she established protein analysis systems for active service. Between 2015 and 2020, she completed two individual research projects as the principal investigator, one supported by the university and the other by the Turkish Diabetes Foundation (within the scope of the 2016 Best Scientific Project Award). She conducted research using in vivo and in vitro experimental models of diabetes/insulin resistance and investigated the electrophysiological and molecular mechanisms underlying diabetic cardiomyopathy/cardiac insulin resistance. Her current research focus is on elucidating the electrophysiological and molecular processes of neuronal dysfunctions.

Dr. Esma Nur Zeydanlı has 18 international research articles indexed in Web of Science (SSCI), with a total of 562 citations, an hindex of 14, and an i10index of 16. She teaches in the Neuroscience Master’s and PhD Programs and serves as a member of the executive board.

Graduate Students Supervised;
Neuroscience: Master’s Graduate (one), Master’s (one), PhD (two)
Molecular Oncology: Master’s (one), PhD (one)
Molecular Biology and Genetics: Master’s (one)

She has been continuing her academic activities at İstinye University since 2019 and, in addition to her academic work, contributes to administrative activities.

Administrative Committees;

ISU Faculty of Medicine Measurement and Evaluation Committee Member (2020–2024, 2025–Ongoing),

ISU Faculty of Medicine Quality and Continuous Improvement Committee Member (2022–2024),

ISU Faculty of Medicine Medical Education Coordinators Committee Member (2020–2025),

ISU Faculty of Medicine Self-Evaluation Committee Member (2022–Ongoing),

ISU Faculty of Medicine Quality Committee Member (2025–Ongoing),

ISU Faculty of Medicine Disciplinary Committee Member (2025–Ongoing),

ISU Faculty of Medicine Advisory Board Member (2025–Ongoing),

ISU Faculty of Medicine Program Development Committee Member (2025–Ongoing),

Coordinator Roles;

ISU Faculty of Medicine Elective Courses Coordinator (2025–Ongoing),

ISU Faculty of Medicine Student Coordinator (2025–Ongoing)

Articles

Enhancement of Cellular Antioxidant-Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn2+and Ca2+and Prevention of RyR2-Leak in Hyperglycemic Cardiomyocytes , 2014
Pioglitazonun Metabolik Sendromlu Sıçan Kalp Fonksiyonuna Etkisinin Elektrofizyolojik Yöntemlerle İncelenmesi , 2015
ß Blocker Timolol Prevents Arrhythmogenic Ca2 Release and Normalizes Ca2 and Zn2 Dyshomeostasis in Hyperglycemic Rat Heart , 2013
Selenium restores defective beta adrenergic receptor response of thoracic aorta in diabetic rats , 2010
Profiling of cardiac adrenoceptor subtypes in the cardiac left ventricle of rats with metabolic syndrome Comparison with streptozotocin induced diabetic rats , 2015
Pioglitazonun metabolik sendromlu sıçan kalp fonksiyonuna etkisinin elektrofizyolojik yöntemlerle incelenmesi , 2015
Omega 3E treatment regulates matrix metalloproteinases and prevents vascular reactivity alterations in diabetic rat aortaThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research , 2009
Intracellular free zinc during cardiac excitation contraction cycle calcium and redox dependencies , 2011
Interplay Between Cytosolic Free Zn2 and Mitochondrion Morphological Changes in Rat Ventricular Cardiomyocytes , 2016
High carbohydrate diet induced myocardial remodelling in rats , 2015
Enhancement of Cellular Antioxidant Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn2 and Ca2 and Prevention of RyR2 Leak in Hyperglycemic Cardiomyocytes , 2014
Doxycycline Ameliorates Vascular Endothelial and Contractile Dysfunction in the Thoracic Aorta of Diabetic Rats , 2011
Cardioprotective effect of propranolol on diabetes induced altered intracellular Ca2 signaling in rat , 2011
Antioxidants but not Doxycycline Treatments Restore Depressed Beta Adrenergic Responses of the Heart in Diabetic Rats , 2009
title Electrophysiological basis of metabolic syndrome induced cardiac dysfunction sup 1 sup title , 2016
Antioxidants but not Doxycycline Treatments Restore Depressed Beta-Adrenergic Responses of the Heart in Diabetic Rats , 2009
Azoramide improves mitochondrial dysfunction in palmitate-induced insulin resistant H9c2 cells , 2019
The Contribution of Phosphodiesterases to Cardiac Dysfunction in High Carbohydrate Diet-Induced Metabolic Syndrome Rats , 2019
Doxycycline Ameliorates Vascular Endothelial and Contractile Dysfunction in the Thoracic Aorta of Diabetic Rats , 2011
Profiling of cardiac β-adrenoceptor subtypes in the cardiac left ventricle of rats with metabolic syndrome: Comparison with streptozotocin-induced diabetic rats , 2015
Omega-3E treatment regulates matrix metalloproteinases and prevents vascular reactivity alterations in diabetic rat aortaThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research. , 2009
Selenium restores defective beta-adrenergic receptor response of thoracic aorta in diabetic rats , 2010
Intracellular free zinc during cardiac excitation–contraction cycle: calcium and redox dependencies , 2011
Cardioprotective effect of propranolol on diabetes-induced altered intracellular Ca2 signaling in rat , 2011
ß-Blocker Timolol Prevents Arrhythmogenic Ca2 Release and Normalizes Ca2 and Zn2 Dyshomeostasis in Hyperglycemic Rat Heart , 2013
Interplay Between Cytosolic Free Zn2+ and Mitochondrion Morphological Changes in Rat Ventricular Cardiomyocytes , 2016
Investigation on the cross talk between 3 Adrenergic receptor and Zn2 signalling indiabetic cardiomyocytes , 2016
Electrophysiological basis of metabolic syndrome induced cardiac dysfunction title , 2016
Cardioprotective effect of selenium via modulation of cardiac ryanodine receptor calcium release channels in diabetic rat cardiomyocytes through thioredoxin system , 2013
Improvement of Functional Recovery of Donor Heart Following Cold Static Storage with Doxycycline Cardioplegia , 2014
Age related regulation of excitation contraction coupling in rat heart , 2011
Antioxidant Treatments Improve Diabetes Induced Endothelium Dependent Vascular Dysfunction , 2009
High carbohydrate diet induced myocardial remodeling in rats , 2015

Reports

Monitoring of intracellular free Zn2+ and Ca2+ changes in cardiomyocytes from metabolic syndrome rats - TOY AYŞEGÜL,OKATAN ESMA NUR,DEĞİRMENCİ SİNAN,TURAN BELMA
An investigation on the antioxidant activity of azoramide, a promising new anti-diabetic, in palmitate-induced insulin resistance in H9c2 cells - OKATAN ESMA NUR
Beneficial Effects Of Azoramide On Palmitate-Induced Insulin Resistance In H9c2 - OKATAN ESMA NUR
Azoramidin Anti-Diyabetik Etkisinde İnsülinin Sinerjistik Rolü - OKATAN ESMA NUR
Mitochondria-directed approaches seem to play important role in the cellular therapy of cardiac dysfunction - OKATAN ESMA NUR,BİLLUR DENİZ,OLĞAR YUSUF,TUNCAY ERKAN,TURAN BELMA
Roles of oxidant stress and matrix metalloproteinases in endothelium- dependent relaxation of diabetic rat thorasic aorta - OKATAN ESMA NUR,BİLGİNOĞLU AYÇA,aydemir köksoy aslıhan,TURAN BELMA
Matrix metalloproteinases contribute to diabetes induced cardiovascular dysfunction - aydemir köksoy aslıhan,OKATAN ESMA NUR,BİLGİNOĞLU AYÇA,GÜRDAL HAKAN,schulz richard,TURAN BELMA
ZINC RELEASE MODULATES CARDIAC RYANODINE RECEPTORS - BİLGİNOĞLU AYÇA,OKATAN ESMA NUR,tuncay erkan,SEYMEN AYTAÇ,TURAN BELMA
Profiling of cardiac beta-adrenoceptor subtypes in left ventricle from metabolic syndrome rat heart: Comparison with streptozotocin-diabetic rat. - OKATAN ESMA NUR,TUNCAY ERKAN,TOY AYŞEGÜL,HAFEZ GAYE,TURAN BELMA
Pre-diyabet oluşturulmuş sıçanlarda kardiyomiyositlerin ışık mikroskobunda değerlendirilmesi. - NAKKAŞ HİLAL,KIZIL ŞULE,OKATAN ESMA NUR,CAN BELGİN,TURAN BELMA
Yüksek karbonhidrat diyeti etkisinin sıçan kalbi ince-yapı bulguları ile gösterilmesi. - NAKKAŞ HİLAL,KIZIL ŞULE,OKATAN ESMA NUR,CAN BELGİN,TURAN BELMA
Doxycycline regulates intracellular zinc in diabetic rat heart via regulation of cellular redox cycle - TUNCAY ERKAN,OKATAN ESMA NUR,TURAN BELMA
Timolol treatment of diabetic rats improved basal cardiac function and responses to 3 but not 1 and 2 receptors stimulations - TUNCAY ERKAN,OKATAN ESMA NUR,TURAN BELMA
Depressed Sarcoplasmic Reticulum Activity Underlies Ca2 Dyshomeostasis in A Rat Model of Metabolic Syndrome - OKATAN ESMA NUR,TUNCAY ERKAN,TURAN BELMA
Intracellular Zn 2 Release Modulates Cardiac Ryanodine Receptor Function and Cellular Activity - OKATAN ESMA NUR,TUNCAY ERKAN,SEYMEN Aytac A,BİLGİNOĞLU AYÇA,SOZMEN Nazlı N,VASSORT Guy
Beneficial Effect Of Sodium Selenate On Vascular Dysfunction In Diabetic Rats International Societyfor Heart Research - OKATAN ESMA NUR,TANRIVERDİ Evrim,SEYMEN Aytaç A,TUNCAY ERKAN,GÜRDAL HAKAN,KÖKSOY Aslıhan,TURAN BELMA
Intracellular free Zn2 increase induces marked changes in mitochondrial function and ultrastructure in cardiac cells - TUNCAY ERKAN,OKATAN ESMA NUR,BİLLUR DENİZ,CAN BELGİN,TURAN BELMA
Intracellular free Zn2 increase induces marked changes in mitochondrial function and ultrastructure in cardiac cells - TUNCAY ERKAN,OKATAN ESMA NUR,BİLLUR DENİZ,CAN BELGİN,TURAN BELMA
Investigation on the cross talk between 3 Adrenergic receptor and Zn2 signalling in diabetic cardiomyocytes - TURAN BELMA,TUNCAY ERKAN,OKATAN ESMA NUR
Investigation on the cross talk between 3 Adrenergic receptor and Zn 2 signaling in diabetic cardiomyocytes - TUNCAY ERKAN,OKATAN ESMA NUR,TURAN BELMA
Intracellular free Zn2 increase induces marked changes in mitochondrial function and ultrastructure in cardiac cells - TUNCAY ERKAN,OKATAN ESMA NUR,BİLLUR DENİZ,CAN BELGİN,TURAN BELMA
Monitoring of intracellular free Zn2 and Ca2 changes in cardiomyocytes from metabolic syndrome rats - TOY AYŞEGÜL,OKATAN ESMA NUR,DEĞİRMENCİ SİNAN,TURAN BELMA
Depressed Sarcoplasmic Reticulum Activity Underlies Ca2 Dyshomeostasis in A Rat Model of Metabolic Syndrome - OKATAN ESMA NUR,erkan tuncay,TURAN BELMA
Monitoring of intracellular free Zn2 and Ca2 changes in cardiomyocytes from metabolic syndrome rats - TOY AYŞEGÜL,OKATAN ESMA NUR,DEĞİRMENCİ SİNAN,TURAN BELMA
Depressed Sarcoplasmic Reticulum Activity Underlies Ca2 Dyshomeostasis in A Rat Model of Metabolic Syndrome - OKATAN ESMA NUR,Tuncay Erkan,TURAN BELMA
Alterated Intracellular Calcium Ion Regulation Plays Important Role in High Carbohdyrate Intake Induced Myocardial Remodeling - OKATAN ESMA NUR,TOY AYŞEGÜL,TURAN BELMA
Doxycycline ameliorates diabetes induced vascular dysfunction - OKATAN ESMA NUR,TURAN BELMA
Diyabetli sıçan damar düz kası A1 Adrenerjik yanıtlarında matriksmetalloproteinazlar ve oksidan stresin rolü - OKATAN ESMA NUR,TURAN BELMA
Roles of oxidant stress and matrix metalloproteinases in endothelium dependent relaxation of diabetic rats - OKATAN ESMA NUR,TURAN BELMA
Role of intracellular zinc on phosphorylation level of cardiac ryanodineReceptors in normoglycemic and hyperglycemic rats - OKATAN ESMA NUR,TURAN BELMA
EFFECTS OF ASTRAGALUS EXTRACT ON OXIDANT ANTIOXIDANT STATUS AND MYOCARDIAL CONTRACTILITY IN STREPTOZOCIN INDUCED DIABETIC RATS - NAMUSLU MEHMET,OKATAN ESMA NUR,TURAN BELMA,DURAK İLKER
Beneficial role of selenium on diabetes induced altered adrenergic receptorresponse of aortic smooth muscle of the rats - OKATAN ESMA NUR,TURAN BELMA
Oxidative stress plays important role on cardiac ryanodine receptor calciumrelease channels in diabetic rats - OKATAN ESMA NUR,TURAN BELMA
Oksidatif stresin kardiyak ryanodin reseptörleri üzerine etkisinin diyabetik sıçankalplerinde incelenmesi - OKATAN ESMA NUR,TURAN BELMA
Cardioprotective effect of sodium selenate or thioredoxin through ryanodinereceptor modulation - OKATAN ESMA NUR,TURAN BELMA
Investigation of in vitro effect of timolol on sarcoplasmic reticulum functionin streptozotocin induced diabetic rat heart - OKATAN ESMA NUR,TURAN BELMA
Metabolik sendromlu sıçanlarda kalbin elektriksel ve mekanik aktivitesi üzerine bir çalışma - OKATAN ESMA NUR,TURAN BELMA
An electrophysiological investigation on cardiac function from ratssupplemented with high carbohydrate diet - OKATAN ESMA NUR,TURAN BELMA
Yüksek Sükrozla İndüklenen Metabolik Sendromlu Sıçan Kardiyomiyositlerinde Hücre İçi Ca2 Homeostazına Etkili Faktörlerin İncelenmesi - OKATAN ESMA NUR,TURAN BELMA
Yüksek Sükrozla İndüklenen Metabolik Sendromlu Sıçan Kardiyomiyositlerinde Hücre İçi Ca2 Homeostazına Etkili Faktörlerin İncelenmesi - OKATAN ESMA NUR,TURAN BELMA
Timolol Treatment of Diabetic Rats Improved Basal Cardiac Function and Responses to 3 but not 1 and 2 receptors Stimulations - TUNCAY ERKAN,OKATAN ESMA NUR,TURAN BELMA
A Comparative Study on Beneficial Effects of Antioxidants on Diabetes induced Cardiac Contractile Dysfunction - TUNCAY ERKAN,TURAN BELMA
Increased Oxidative Stress Triggers Marked Intracellular Zinc Elevation in Cardiomyocytes Under Hyperglycemia - TUNCAY ERKAN,LYON Alexander R,RUTTER Guy A,TURAN BELMA
Hücre İçi Serbest Zn 2 nun Kardiyomiyositlerde Uyarılma Kasılma Çiftlenimindeki Rolü - TUNCAY ERKAN,OKATAN ESMA NUR,TURAN BELMA
Determination of Cytosolic Endoplasmic Reticulum and Mitochondrial Free Zinc Levels in Cardiomyocytes by Using Genetically Encoded Zinc Sensitive FRET Sensors - TUNCAY ERKAN,LYON Alexander R,TURAN BELMA,RUTTER Guy A

Awards

TÜRKİYE DİYABET VAKFI DIABETES MELLITUS BİLİMSEL PROJE DESTEK ÖDÜLÜ – 2016
BÖLÜME EN YÜKSEK NOT İLE GİRİŞ – 2002
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2009
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2008
FEN FAKÜLTESİ KAPSAMINDA ÜÇÜNCÜLÜKLE MEZUNİYET – 2006
BİYOLOJİ BÖLÜMÜNDEN BİRİNCİLİKLE MEZUNİYET – 2006
YÜKSEK LİSANS BURSU – 2006
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2010
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2008
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2009
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2010
POSTER ÖDÜLÜ – 2013
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2011
POSTER ÖDÜLÜ – 2016
BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ – 2012

Assistant Professor Esma Nur Zeydanli - İstinye Üniversitesi

esma.zeydanli@istinye.edu.tr

Research Areas

Sağlık Bilimleri Temel Alanı
Fen Bilimleri ve Matematik Temel Alanı
Biyofizik
Biyoloji

Academic Member

Assistant Professor Esma Nur Zeydanli

Temel Tıp

Articles

Reports

Awards

Research Areas