Profesör ATİLLA AKDEMİR

Makaleler

• The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups , 2020
• Thiosemicarbazone-benzene Sulfonamide Derivatives as Human Carbonic Anhydrases Inhibitors: Synthesis, Characterization, and In silico Studies , 2024
• Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors , 2020
• Dithiocarbamates and dithiocarbonates containing 6-nitrosaccharin scaffold: Synthesis, antimycobacterial activity and in silico target prediction using ensemble docking-based reverse virtual screening , 2023
• Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors , 2020
• Evaluation of new 2-hydroxy-N-(4-oxo-2-substituted phenyl-1,3- thiazolidin-3-yl)-2-phenylacetamide derivatives as potential antimycobacterial agents , 2020
• Design and synthesis of novel peptidomimetics for cancer immunotherapy , 2020
• Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies , 2022
• Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII , 2022
• Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands In silico docking pharmacological screening and X ray analysis , 2009
• Use of Acetylcholine Binding Protein in the Search for Novel α7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-ray Analysis , 2009
• Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment , 2020
• New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study , 2021
• Synthesis of new 1,2,4‐triazole–(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis , 2021
• In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone , 2021
• The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies , 2022
• Synthesis, anti‐TB activities, and molecular docking studies of 4‐(1,2,3‐triazoyl)arylmethanone derivatives , 2022
• Mandelic acid-based spirothiazolidinones targeting M. tuberculosis: Synthesis, in vitro and in silico investigations , 2022
• New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors , 2022
• New Pyridinium Salt Derivatives of 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5- sulfonamide as Selective Inhibitors of Tumour-Related Human Carbonic Anhydrase Isoforms IX and XII , 2022
• Anti-SARS-CoV-2 and cytotoxic activity of two marine alkaloids from green alga Caulerpa cylindracea Sonder in the Dardanelles. , 2022
• Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies , 2020
• Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors , 2019
• Novel Indole-Based Hydrazones as Potent Inhibitors of the alpha-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae , 2020
• Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII , 2019
• Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII , 2019
• Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies , 2019
• A Class of Sulfonamides with Strong Inhibitory Action against the Carbonic Anhydrase from Trypanosoma cruzi , 2013
• Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides , 2013
• Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: Synthesis, biological evaluation and molecular modelling studies , 2014
• A Class of Sulfonamides with Strong Inhibitory Action against the alpha-Carbonic Anhydrase from Trypanosoma cruzi , 2013
• Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme , 2015
• Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor associated hCA XII isozyme , 2014
• Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme , 2019
• Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme , 2019
• Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action , 2015
• Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII , 2015
• New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies , 2015
• Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies , 2015
• Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives , 2016
• A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome , 2016
• A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms , 2016
• Isatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes , 2016
• Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms , 2017
• Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators , 2017
• Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold , 2019
• Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies , 2019
• Target Recognition Molecules and Molecular Modeling Studies , 2017
• Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors , 2018
• A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives , 2018
• Aromatase Inhibition by 2-methyl indole hydrAzone derivatives evaluated via molecular docking and in vitro activity studies , 2018
• Computer design synthesis and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis , 2017
• Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases , 2017
• Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis , 2017
• A G q 11 coupled mutant histamine H 1 receptor F435A activated solely by synthetic ligands RASSL , 2005
• Fragment growing induces conformational changes in acetylcholine binding protein a structural and thermodynamic analysis , 2011
• Acetylcholine binding protein AChBP as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors , 2011
• Structure based design synthesis and structure activity relationships of dibenzosuberyl and benzoate substituted tropines as ligands for acetylcholine binding protein , 2012
• Identification of novel 7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric 7 receptor ligand binding domain , 2012
• The extremo carbonic anhydrase CA from Sulfurihydrogenibium azorense the fastest CA known is highly activated by amino acids and amines , 2013
• o Benzenedisulfonimido sulfonamides are potent inhibitors of the tumor associated carbonic anhydrase isoforms CA IX and CA XII , 2013
• Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo , 2013
• Inhibition of tumor associated human carbonic anhydrase isozymes IX and XII by a new class of substituted phenylacetamido aromatic sulfonamides , 2013
• Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid Synthesis biological evaluation and molecular modelling studies , 2014